Abstract
IntroductionIntra-lesional injections of collagenase (Xiapex®) were the only non-invasive treatment option for Peyronie's disease (PD), until their withdrawal from the European market. ObjectiveTo evaluate the feasibility, efficacy, and safety of a combined treatment of percutaneous needle tunnelling (PNT) with penile modelling (PM) and the injection of platelet-rich plasma (PRP) under general anesthesia in the treatment of PD. Patients and methodA prospective case series study included patients with PD in a stable phase who underwent this procedure between March 2020 and January 2023. The main outcome was an improvement in curvature. ResultThirty-six patients underwent this novel approach for the treatment of PD. The pretreatment mean±standard deviation (SD) curvature degree was 57.5±20.61° (range 20–90°). After the protocol, the mean curvature degree was 40.86±25.13° (range 0–90°). The curvature angle improved significantly (P=0.0001), with a mean improvement difference of 16.85±14.81° (range 0–50°) and a mean improvement percentage of 47.7±40.29% (range 0–100%). ConclusionOur preliminary experience suggests that PNT and PRP injections with PM are effective and safe for the treatment of penile deformity of PD. Level of evidence4: case series study
Published Version
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