Abstract
Lactobacillus species are non-spore-forming, gram-positive bacteria and lactic acid producing bacteria (LAPB) that naturally inhabit the human and animal gastrointestinal and mouth organs. The aim of this review was to evaluate the new progress regarding the use of Lactobacillus species as live delivery vectors, prevention, and treatment of pathogenic and metabolic diseases. Lactobacillus strains of probiotics have been extensively studied and have confirmed that they can absolutely improve performance as live delivery vectors, a treatment option of various diseases such as: Hemorrhagic cecal coccidiosis in young poultry, hypertension, avian flu, obesity, diabetes, Derzsy’s disease or parvovirus infection, human immunodeficiency virus infections, irritable bowel syndrome, gastrointestinal disorders, Fungal infections, vaginal eubiosis, fish and shellfish species diseases. We give you an idea about that Lactobacillus species have been proficient in preventing and treating both disorders in animal models and some are used for clinical trials. We present the most current studies on the use of Lactobacillus strains that had an impact on an effective immune response to a specific antigen because a variety of antigens have been expressed. Therefore Lactobacillus strains can be considered as good candidates because of its potential for diseases treatment and vaccine development as heterologous protein secretion to date.
Highlights
Lactic acid bacteria (LAB) are gram-positive bacteria and nonpathogenic
The recent year’s research studies from 2015 to 2017 published in English language regarding the use of newly developed technology and analytic methods of lactic acid bacteria as live delivery vectors, treatment of diseases, and immune responses vaccines in different host species focusing on Lactobacillus species
Lactobacillus species are an important part of normal intestinal microbiota of various mammalian species and is the best characterized and widely commercialized probiotic because they provide an affordable means for prevention and treatment of various infectious, allergic and inflammatory conditions as demonstrated in numerous animal and human studies [44] [45]
Summary
Lactic acid bacteria (LAB) are gram-positive bacteria and nonpathogenic They are considered to be generally regarded as safe (GRAS) organisms [1] [2] and daily ingested by humans playing significant roles as health-promoting probiotics which is the most important point, to improve general health and protect from different kinds of illness [3] [4] [5] [6]. Probiotic bacteria in the Lactobacillus genera are capable to have therapeutic effects in the patients of psychological disorders, such as depression, anxiety, and memory [25] [26] [27]
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