Abstract
A comparative study with two groups of 25 rats each was undertaken in order to study fluid milk fortified with SFE-171 (stabilized FeSO 4 by micro encapsulation with phospholipids) or FeSO 4, both labeled with 59Fe. After the administration of either product, its total absorption, biodistribution and incorporation of iron into hemoglobin was determined for both cases. In the first case the total absorption was (28.3 ± 6.0)%, whereas in the second it was (24.1 ± 5.8)%, the difference between both values is statistically significant with a P < 0.01. The biodistribution results show that the iron from SFE-171 follows the same metabolic pathway than that from FeSO 4. The highest amount (approximately 80%) was found in blood, followed by the liver with approximately 11% and bones with a proportion somewhat higher than 4%, the activity in intestine was minimal in both cases. The 59Fe in blood was found 18 days after the administration of either product at a 100% in the red blood cells, which implies that the iron administered in the milk fortified with SFE-171 or with FeSO 4 was incorporated into hemoglobin. These results indicate with a high degree of significance that the fortification of milk with SFE-171 is a procedure which assures the effective absorption of iron and a physiological behavior of this element.
Published Version
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