Abstract
New Pd(II) and Pt(IV) triazine complexes [Pt3(L1)2(Cl)9(H2O)3].3Cl.3H2O (1), [Pt3(L2)2(Cl)9(H2O)3].3Cl (2), [Pt3(L3)2(Cl)9(H2O)3].3Cl (3), [Pt2(L4)2(Cl)6(H2O)2] .2Cl.4H2O (4), [Pd3(L1)2(H2O)6] .3Cl2 (5), [Pd3(L2)2(H2O)6].3Cl2 (6), [Pd3(L3)2(H2O)6].3Cl2 (7), and [Pd2(L4)2(H2O)4].2Cl2 (8) were synthesized and well characterized using elemental analyses, molar conductance, IR, UV-Vis, magnetic susceptibility, 1H, 13C-NMR spectra, and thermal analyses. These analyses deduced that the L1, L2, and L3 ligands act as tridentate forming octahedral geometry with Pt(IV) metal ions and square planar geometry in case of Pd(II) complexes but the L4 ligand acts as bidentate chelate. The molar conductance values refer to the fact that all the prepared s-triazine complexes have electrolyte properties which are investigated in DMSO solvent. Surface morphology behaviors of prepared complexes have been scanned using TEM. The crystalline behavior of triazine complexes has been checked based on X-ray powder diffraction patterns. The antimicrobial activity of the free ligands and their platinum(IV) and palladium(II) complexes against the species Staphylococcus aureus (G+), Escherichia coli (G−), Aspergillus flavus, and Candida albicans has been carried out and compared with the standard one. The coordination of ligands towards metal ions makes them stronger bacteriostatic agents, thus inhibiting the growth of bacteria and fungi more than the free ligands. The cytotoxic assessment IC50 of the free ligands and its platinum(IV) complexes in vitro against human colon and lung cancer cell lines introduced a promising efficiency.
Highlights
The s-triazine and its derivatives have a wide range of pharmaceutical benefits: antiviral, antimalarial, antibacterial, anti-inflammatory, antileukemia, anticancer, and anti-HIV activities [1,2,3,4]
It was refereed that the organic s-triazine’s derivative compounds and transition metal complexes have been found to be effective in the field of nonlinear optical activity (NLO) [10,11,12] that can act as an auxiliary acceptor in NLO chromophores
The synthesis of L1, L2, L3, and L4 triazine ligands was carried out according to our previously work [29], L1 prepared by stirring the mixtures of 2-aminopyrimidine with 6-chloro-N2-(4-chlorophenyl)-N4di(pyrimidin-2-yl)-1,3,5-triazine-2,4-diamine in dioxane at refluxed temperature; L2 prepared by stirring the mixtures of 2-aminothiazole with 6-chloro-N2-(4-chlorophenyl)-N4(pyrimidin-2-yl)-1,3,5-triazine-2,4-diamine in dioxane at refluxed temperature; L3 prepared by stirring the mixtures of 2-aminopyrimidine with 4,6-dichloro-N2-(1H-1,2,4-triazol3-yl)-1,3,5-triazin-2-amine in dioxane 50∘C; L4 prepared by stirring the mixtures of 2-aminopyrimidine with 4,6dichloro-N-( 4-chlorophenyl)-1,3,5-triazin-2-amine in dioxane 50∘C
Summary
The s-triazine and its derivatives have a wide range of pharmaceutical benefits: antiviral, antimalarial, antibacterial, anti-inflammatory, antileukemia, anticancer, and anti-HIV activities [1,2,3,4]. Many triazine analogues are utilized as a building block for the construction of multisite ligand systems [5, 6]. A number of triazine analogues were tested for ion extraction of metal ions which have been reviewed [7, 8]. 1,3,5-Triazine is considered to be a remarkable in supramolecular chemistry since it can take part in all types of interactions, namely, coordination, hydrogen bonds, electrostatic and chargetransfer attractions, and aromatic-stacking interactions [15] Further advantages in considering the s-triazine as central moiety are its symmetric nature by which it will be possible to chemically tune its NLO nature by mono- or disubstitution [13, 14]. 1,3,5-Triazine is considered to be a remarkable in supramolecular chemistry since it can take part in all types of interactions, namely, coordination, hydrogen bonds, electrostatic and chargetransfer attractions, and aromatic-stacking interactions [15]
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