Abstract
The meadowsweet (Filipendula vulgaris) extract in a greater degree, than valerian extract improves in albino rat's brain the kinetic characteristics of mitochondrion respiratory activity, increases the association of substrate oxidation with ADP phosphorylation in experimental posthypoxic encephalopathy. The nettle (Urtica dioica) extract increases in albino rat's brain the rate of cycle Krebs substrate utilization and oxidative phosphorylation coupling in experimental inhibition of fatty acids p-oxidation caused with 4-pentenoic acid. The meadowsweet and nettle extracts posses the expressed antioxidant effect.
Highlights
Ýêñòðàêò ëàáàçíèêà îáûêíîâåííîãî â áîëüøåé ñòåïåíè, ÷åì ýêñòðàêò âàëåðèàíû, óëó÷øàåò â ãîëîâíîì ìîçãå áåëûõ êðûñ êèíåòè÷åñêèå õàðàêòåðèñòèêè äûõàòåëüíîé àêòèâíîñòè ìèòîõîíäðèé, óâåëè÷èâàåò ñîïðÿæåííîñòü ñóáñòðàòíîãî îêèñëåíèÿ ñ ôîñôîðèëèðîâàíèåì ïðè ýêñïåðèìåíòàëüíîé ïîñòãèïîêñè÷åñêîé ýíöåôàëîïàòèè
The nettle (Urtica dioica) extract increases in albino rat’s brain the rate of cycle Krebs substrate utilization and oxidative phosphorylation coupling in experimental inhibition of fatty acids -oxidation caused with 4-pentenoic acid
 ìèòîõîíäðèÿõ ïî ñðàâíåíèþ ñ ïîêàçàòåëÿìè â îòäàëåííûé ïåðèîä èíãèáèðîâàíèÿ -îêèñëåíèÿ æèðíûõ êèñëîò äûõàòåëüíàÿ àêòèâíîñòü ïîâûøàëàñü â 1,5—2,7 ðàçà âî âñåõ ìåòàáîëè÷åñêèõ ñîñòîÿíèÿõ, ôîñôîðèëèðîâàíèå ÀÄÔ óñêîðÿëîñü â 1,4—2,5 ðàçà, ñîïðÿæåííîñòü îêèñëèòåëüíîãî ôîñôîðèëèðîâàíèÿ âîçðàñòàëà ïðè îêèñëåíèè ýíäîãåííûõ, ÍÀÄ-çàâèñèìûõ ñóáñòðàòîâ è ñóêöèíàòà
Summary
Burkova V.N., Vengerovsky A.I., Suslov N.I., Kaigorodtsev A.V., Nasanova O.N., Yatsenkov A.I., Grishina Ye.I., Melik-Gaikazyan Ye.V., Fisanova L.L. Ýêñòðàêò ëàáàçíèêà îáûêíîâåííîãî â áîëüøåé ñòåïåíè, ÷åì ýêñòðàêò âàëåðèàíû, óëó÷øàåò â ãîëîâíîì ìîçãå áåëûõ êðûñ êèíåòè÷åñêèå õàðàêòåðèñòèêè äûõàòåëüíîé àêòèâíîñòè ìèòîõîíäðèé, óâåëè÷èâàåò ñîïðÿæåííîñòü ñóáñòðàòíîãî îêèñëåíèÿ ñ ôîñôîðèëèðîâàíèåì ïðè ýêñïåðèìåíòàëüíîé ïîñòãèïîêñè÷åñêîé ýíöåôàëîïàòèè. Êëþ÷åâûå ñëîâà: ýêñïåðèìåíòàëüíûå ïîñòãèïîêñè÷åñêàÿ ýíöåôàëîïàòèÿ è èíãèáèðîâàíèå -îêèñëåíèÿ æèðíûõ êèñëîò, ìèòîõîíäðèè ãîëîâíîãî ìîçãà, ïåðåêèñíîå îêèñëåíèå ëèïèäîâ, ýêñòðàêòû ëàáàçíèêà îáûêíîâåííîãî, êðàïèâû äâóäîìíîé è âàëåðèàíû. The nettle (Urtica dioica) extract increases in albino rat’s brain the rate of cycle Krebs substrate utilization and oxidative phosphorylation coupling in experimental inhibition of fatty acids -oxidation caused with 4-pentenoic acid. Òîìñê) ÿâëÿåòñÿ èçâåñòíûì öåíòðîì ïî èçó÷åíèþ ëåêàðñòâåííûõ ðàñòåíèé Ñèáèðè.  äàííîé ñòàòüå ïðèâåäåíû ðåçóëüòàòû âûïîëíåííûõ â ïîñëåäíèå ãîäû íà êàôåäðå ôàðìàêîëîãèè ÑèáÃÌÓ èññëåäîâàíèé âëèÿíèÿ íà áèîýíåðãåòèêó ãîëîâíîãî ìîçãà íîâîãî ïðîòèâîòðåâîæíîãî ñðåäñòâà — ýêñòðàêòà ëàáàçíèêà îáûêíîâåííîãî è àíòèîêñèäàíòíîãî ñðåäñòâà — ýêñòðàêòà êðàïèâû äâóäîìíîé
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