Abstract
A [ReO(Imz)(Hyd)(H2O)2OH] complex was successfully synthesized by the ligand exchange method using oxorhenuim citrate and an imidazole /Hydanton mixed ligand system. Geometry optimization of complex has been carried out using DFT at the B3LYP/LANL2DZ functional in singlet state. B3LYP predicated infrared spectrum of the geometrically optimized structure using the same level of the theory and the same base set showed good agreement with experimentally observed values. The spin allowed singlet-singlet electronic transition of the [ReO(Imz)(Hyd) (H2O)2OH] complex was calculated with time dependent density function theory (TD-DFT) and the UV-Vis spectra has been discussed on this basis. The complex was characterized using microanalysis and IR, UV-Vis, NMR and mass spectroscopic. The technetium tracer [99mTcO(Imz)(Hyd) (H2O)2OH] has also been synthesized by two methods using 99mTc-gluconate as a precursor or; by direct reduction. The radiochemical purity of the complex was over 95% as measured by thin layer chromatography. In vitro studies showed that the complex possessed good stability under physiological conditions. The partition coefficient indicated that the complex hydrophilic and the electrophoresis results showed that the complex cationic. Biodistrbution in mice showed that the complex accumulated in heart uptake of 9.53±3.87 % ID/gm at 5 min and good retention (6.37±1.21) % ID/gm at 60 min. One hour after the injection, the heart/liver, heart/lung and heart/blood radioactivity ratios were 0.46, 1.04 and 0.56, respectively. These findings indicate that the complex might be suitable for myocardial imaging.
Highlights
Many metallic elements play a crucial role in living systems
We have studied the radiochemical properties of the corresponding technetium complex, which was prepared by two methods
The reaction between oxorhenium citrate and the imdizole/hydantoin mixed ligands system lead to the formation of a[ReO(Imz)(Hyd) OH(H2O)2] complex according to Scheme 1
Summary
Many metallic elements play a crucial role in living systems. As a result of their tendency to lose electrons to form positively charged ions, metals readily interact with electron rich biological molecules such as proteins and DNA, or bind with small molecules that are vital to life, such as oxygen. Because metals are so extensively used in biological systems, it was reasonable to investigate the potential use of metal ions alone and incorporated into drugs as well as the use of coordination complexes for medicinal purposes [1]. The coordination chemistry of the metal will determine the ultimate geometry and stability of the radiopharmaceutical [1]. Radiopharmaceuticals, i.e., chemicals or cellular structures that include a radionuclide, are routinely used in nuclear medicine, for both diagnostic and treatment purposes. The coordination chemistry of rhenium and technetium is currently attracting much attention due to the radionuclide-based application in radiopharmaceuticals. Rhenium belongs to the same group of the periodic table (VII) as technetium and exhibits similar chemical properties. Rhenium is often used as a non-radioactive alternative to technetium for struc-
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