New Opportunities of Topic Therapy of Foot Mycosis

Abstract

The objective: to evaluate the efficacy and safety of combined external use of naftifine hydrochloride 1% and salicylic ointment 3% in the treatment of foot mycosis.Materials and methods. Under observation were 12 patients with mycosis of the feet, incl. 7 (58%) women and 5 (42%) men, aged 37 to 69 years. The disease duration ranged from 1 to 13 years. Naftifine hydrochloride 1% and salicylic ointment 3% were prescribed to all patients for 2 weeks once a day. Evaluation of clinical efficacy was performed on days 3, 7, and 14 of the treatment. To assess the mycological recovery, bacterioscopic examination was performed on the 14th day of therapy, as well as on the 7th and 10th day after its termination.Results. Analysis of the regression of the clinical manifestations of the disease showed a high efficacy of the proposed treatment regimen. Already on day 3 of therapy, a marked decrease in itching, erythema, edema, desquamation and hyperkeratosis was observed in all patients. At the time of termination of therapy (14 days), all patients showed clinical recovery, manifested by a complete regression of rash, inflammatory manifestations in the lesions, the absence of hyperkeratosis and complete epithelialization of cracks. Bacterioscopic examination on the 14th day of therapy, as well as on the 7th and 10th day after its termination, negative results were obtained in 100% of patients, which indicated mycological recovery.Conclusions. The proposed combined method of external use of naftifine hydrochloride 1% and salicylic ointment 3% in the treatment of mycosis of the feet is effective and safe, demonstrates a pronounced therapeutic effect, is well tolerated by patients.