Abstract
Two new nor-chamigranes and a new bisabolane sesquiterpene, given the trivial names dactylomelanins CE (1–3), were isolated from the sea hare Aplysia dactylomela along with a known compound (4). Their structures and absolute configurations were elucidated by analysis of their HRESIMS, NMR and ECD spectroscopic data. The position of the bromine atom in the structure of 1 was established by quantum chemical calculations of the NMR chemical shifts and by analysis of DP4+ probability. Compounds 1–4 were evaluated for their cytotoxicity against three cell lines, A549, MCF-7, and HepG2.
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