Abstract
Two new brominated sesquiterpenes (1 and 2) and two previously reported compounds (3 and 4) were isolated from the Vietnamese sea hare Aplysia dactylomela. The new structures were elucidated by spectroscopic analysis combined with density functional theory (DFT) calculations of NMR chemical shifts and 3JH,H coupling constants, and by DP4+ analysis. Compound 2 is the first chamigrane sesquiterpenoid containing the B ring with two epoxide moieties. The absolute configurations of compounds 1 and 3 were determined by quantum chemical electronic circular dichroism (ECD) calculation. Compounds 1, 2, and 4 exhibited moderate or weak cytotoxicity against HepG2, DU145 and A549 cancer cells.
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