New Molecular Imprinting Nano Polymer Synthesis And Characterization As A Biocompatible For Drug Delivery Applications

Abstract

New polymeric nanoparticles were to be developed for biomedical purposes as the purpose of this study. It was thought that theproduction of materials with novel properties and functions could be accomplished by meticulous design and synthesis, as well as theresearch of structure-property connections. A novel method that we developed has excellent sensitivity, cheap cost, and high stability.The molecularly imprinted polymer (MIP) used in this method, which is based on a functional monomer named polylactic acid(PLA), Acrylic acid (AA) , Methylacrylate (MA) Chitosan (Cs), Bisphenol A dimethacrylate(BADMA) , N,Ndimethylacrylamide(DMA), Polyvinylpyrrolidone (PVP), Ethylene glycol(EG), Methyl Methacrylate(MMA). To search into thepotential use of these hydrogels in controlled drug delivery systems, were crosslinked by 1,6 hexanedioldiacrylate (HDODA) andphotoinitiated by 1-hydroxycyclohexyl phenyl ketone before being polymerized using free radical polymerization.We synthesized the water-insoluble, amphiphilic polymer MIPs and for the first time described its structure and characteristics. Thispolymer, which has a nanostructure with a size of about 40-88 nm, is the ideal biocompatible polymer for nanobioapplications.Atenolol was loaded onto a produced hydrogel, and the drug release of such hydrogels in vitro and in vivo was studied. According tothe results, raising the pH accelerated the rate of drug release. Fourier transform infrared and 1HNMR spectroscopy, thermalgravimetric measurement, and scanning electron microscopy were used to analyze the produced hydrogels. I have been studyingabout the TGA and DSC utilizing argon medium gas and a 10 oC/min heating rate. The effect of TGA shows% residue between 2-12% at 500oC and char yield between 26- 50% at 400oC. Nanocopolymer hydrogels' glass transition values (Tg) ranged from 120 to275 °C.The faculty of biological science and biotechnology at Shahid Beheshti University also conducted studies on the efficiency of thesenanocopolymers using laboratory rats., Tehran, Iran on 18 Male Wistar rats weighing 200–240 g and divided rats into several groups,a group of natural control, and other groups for the induction of high pressure by Nacl (1%) and Dexamethasone, which includes ahigh pressure control group, , groups of treatment with polymers loaded with (Atenolol), and high pressure control groups, where Theresults showed that polymers have an obvious effect on lowering blood pressure levels in rats. Additionally, to avoid the issue ofincreased loading (Atenolol) caused by the treatment process (Atenolol), which is normally what happens as a result of an overdose,as well as to reduce the number of periodic blood pressure checks.