New methods and reagents in organic synthesis. 56. Total syntheses of patellamides B and C, cytotoxic cyclic peptides from a tunicate 2. Their real structures have been determined by their syntheses.

Abstract

The proposed structures of patellamides B and C, cytotoxic lipophilic cyclic peptides from a marine tunicate, have been revised on the basis of the spectral data of their partial hydrolysates, and their revised structures have been synthetically confirmed by the use of diphenyl phosphorazidate(DPPA) and diethyl phosphorocyanidate(DEPC).