New methods and reagents in organic synthesis. 51. A synthesis of ascidiacyclamide, a cytotoxic cyclic peptide from ascidian — determination of its absolute configuration

Abstract

A first synthesis of ascidiacyclamide, a cytotoxic cyclic peptide from ascidian, has been achieved through the cyclodimerization with diphenyl phosphorazidate(DPPA), which has unambiguously determined the absolute configuration of ascidiacyclamide as 1 .