Abstract
There-fore, with the increasing prevalence of MRSA and the pros-pect of multiple resistant strains, the need for alternativeanti-MRSA antibiotics becomes more urgent. In the courseof our screening program for new antibiotics against MRSA,we found that a bacterial strain belonging to Cytophagaspecies isolated from a loess collected in Korea producedfour macrolactone class of secondary metabolites, com-pound 1−4 (Fig. 1).The compound 1−4 are all colorless amorphous solid intheir appearance and have pretty similar physic-chemicalproperties such as TLC behavior and their solubilities inseveral solvents. Four compounds show a same TLC behav-ior (Rf 0.67 on Si 60F
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