Abstract
Chronic kidney disease (CKD) is associated with an increased risk of cognitive impairment. Patients with CKD display an increased permeability of the blood-brain barrier. Zimmermann etal. highlighted the implication of potassium efflux in the microglia and its activation, the activation of the interleukin-1b/interleukin-1R pathway, linked to blood-brain barrier permeability and cognitive impairment in CKD. Along with uremic toxicity, this study provides new solid insights about pathophysiological mechanisms of cognitive impairment in CKD, and potential therapeutic targets.
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