Abstract
New insights in the interactions between African trypanosomes and tsetse flies.
Highlights
African trypanosomiases are vector-borne diseases of human and their livestock, with devastating socio-economical consequences for the Sub-Saharan African continent. These diseases are caused by flagellated unicellular parasites named African trypanosomes that are almost exclusively transmitted by the bite of tsetse flies
Two species of African trypanosomes are responsible for Human African Trypanosomiasis (HAT), known as sleeping sickness: Trypanosoma brucei gambiense in Central/West Africa and T. b. rhodesiense in East/Southern Africa
Successful transmission is primarily the outcome of a crosstalk between the trypanosomes and the tsetse fly vector. This enables the parasite to undergo successive rounds of differentiation, proliferation, and migration in different locations of the fly, resulting in a final infective stage that is transmitted to a new mammalian host during each tsetse fly blood-feeding event. This Research Topic hosted in Frontiers in Cellular and Infection Microbiology focuses on the state-of-the-art on some key aspects of the fascinating biological interplay between African trypanosomes and the tsetse fly
Summary
African trypanosomiases are vector-borne diseases of human and their livestock, with devastating socio-economical consequences for the Sub-Saharan African continent. These diseases are caused by flagellated unicellular parasites named African trypanosomes that are almost exclusively transmitted by the bite of tsetse flies. Two species of African trypanosomes are responsible for Human African Trypanosomiasis (HAT), known as sleeping sickness: Trypanosoma brucei gambiense in Central/West Africa and T. b.
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