New Inroads Into Our Understanding of the Tauopathies, Alzheimer's Disease, and the Contribution of Altered Protein Conformation to Human Neurological Disease.

Walter J Lukiw

doi:10.3389/fnins.2021.817983

Abstract

New Inroads Into Our Understanding of the Tauopathies, Alzheimer's Disease, and the Contribution of Altered Protein Conformation to Human Neurological Disease.

Highlights

Departments of Neurology, Neuroscience and Ophthalmology, LSU Health Sciences Center New Orleans, Louisiana State University, New Orleans, LA, United States
A substantial scientific advance has recently been made in the elucidation of the molecular mechanism by which unusually folded, self-associating tau proteins drive the neuropathology of several common types of human neurodegenerative disease
Each of the tauopathies are defined by the progressive accumulation in the brain of microtubule-associated protein tau (MAPT) proteins as complex, multi-component fibrillar aggregates, and their incidence and prevalence correlate strongly with the degree of dementia (Shi et al, 2021; Vaquer-Alicea et al, 2021)

Summary

Introduction

Departments of Neurology, Neuroscience and Ophthalmology, LSU Health Sciences Center New Orleans, Louisiana State University, New Orleans, LA, United States. A substantial scientific advance has recently been made in the elucidation of the molecular mechanism by which unusually folded, self-associating tau proteins drive the neuropathology of several common types of human neurodegenerative disease.

Results

Conclusion