Abstract
Three previously undescribed indole diketopiperazine alkaloids and seventeen known compounds were characterized from Aspergillus sp. JXC-5 by solid fermentation. Their structures were elucidated by spectroscopic methods and HRESIMS, and the absolute configurations were further confirmed by electronic circular dichroism (ECD), induced CD spectra and ML_J_DP4 methods. In the in vitro bioassays, Compound 5 exhibits potent DPPH and ABTS·+ free radicals radical scavenging activities with IC50 values of 19.54 ± 0.39 μM and 26.39 ± 0.09 μM respectively. Compounds 10-12, 14 and 15 exhibited potent ABTS·+ free radicals radical scavenging activity.
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