New human papillomavirus (HPV) types involved in epidermodysplasia verruciformis (EV) in 3 HIV-infected patients: Response to topical cidofovir

Abstract

To the Editor: Epidermodysplasia verruciformis (EV) is a rare genodermatosis conferring abnormal susceptibility to human β-papillomavirus (β-HPV) infection. To date, 18 cases of EV-like eruptions have been reported associated with HIV infection worldwide. 1 Rogers H.D. Macgregor J.L. Nord K.M. Tyring S. Rady P. Engler D.E. et al. Acquired epidermodysplasia verruciformis. J Am Acad Dermatol. 2009; 60: 315-320 Abstract Full Text Full Text PDF PubMed Scopus (92) Google Scholar We report 3 new cases of HIV patients with EV-like eruption diagnosed according to clinical, histologic, and virological features. Our first patient developed EV in 1992 and presented with common warts, perianal condylomas with squamous cell carcinoma (SCC), and oral invasive SCC. Treatment with acitretin (50 mg/d) and interferon alfa-2a (3 MU subcutaneously 3 days/wk) achieved complete clearance of common warts but only partial improvement of EV. Our second patient developed EV in 2002, and imiquimod therapy was ineffective. The third patient who had had EV since 1983 was treated with emollients without response.