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Abstract
Genomic sequences of Tula (TULV) hantavirus were recovered from tissue samples of European common voles Microtus arvalis (subspecies obscurus) captured in Kazakhstan, Central Asia. Phylogenetic analysis of the S genomic segment of Kazakh TULV strains showed that they form distinct, well supported genetic lineage and share a more ancient common ancestor with two Russian lineages of TULV. The deduced sequence of the nucleocapsid (N) protein of Kazakh TULV strains carried specific amino acid signature: T274Q276T281. The Microtus arvalis group includes several sibling species and/or subspecies in Eurasia, indicating recent and ongoing evolutionary radiation. Our data on TULV lineages in Central Asia, the region not studied for hantaviruses earlier, highlight the diversity of both Microtus host and the virus and also their co-evolution.
Highlights
IntroductionTULV was discovered in early 1990s, first as a sequence recovered from a tissue sample of European common vole, Microtus arvalis [3]
Our data on TULV lineages in Central Asia, the region not studied for hantaviruses earlier, highlight the diversity of both Microtus host and the virus and their co-evolution
We present our findings on TULV in Eastern Kazakhstan, Central Asia, the region not studied for hantaviruses earlier
Summary
TULV was discovered in early 1990s, first as a sequence recovered from a tissue sample of European common vole, Microtus arvalis [3] Later it has been isolated in cell culture [4], characterized, both genetically and antigenically [5,6,7] and since used as a safe model to study hantavirus molecular organization and replication [7,8,9,10,11], hantavirus-host interactions [7, 11,12,13,14,15,16,17,18,19] as well as hantavirus genetics and evolution [20,21,22,23]
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