Abstract
New Fecal Bacterial Signature for Colorectal Cancer Screening Reduces the Fecal Immunochemical Test False-Positive Rate in a Screening Population
Highlights
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide, accounting for more than 880,000 deaths in 2018 [1]
Peptostreptococcus stomatis (PTST) and Bacteroides fragilis (BCTF) absolute abundance was significantly higher in the CRC population than in individuals with normal colonoscopy (p = 0.002 and p = 0.017, respectively)
There were no significant differences, a tendency could be observed in Gemella morbillorum (GMLL), as it showed a higher absolute abundance in CRC patients (p = 0.073); PTST and Roseburia intestinalis (RSBI) absolute abundances were higher in the presence of either nonadvanced adenomas (NAAs) or AA (p = 0.056 and 0.060, respectively)
Summary
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide, accounting for more than 880,000 deaths in 2018 [1]. Fecal bacterial signature for colorectal cancer screening reduced FIT false positive results funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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