Abstract
New diterpenes, namely, trichodermanins F–H, with a fused 6-5-6-6 ring system were isolated from the fungus Trichoderma harzianum OUPS-111D-4 separated from a marine sponge Halichondria okadai. These chemical structures were elucidated by 1D and 2D NMR as well as high-resolution fast atom bombardment mass spectrometry (HRFABMS) spectral analyses. We established their absolute stereostructures by application of the modified Mosher’s method or circular dichroism (CD) spectroscopy. In addition, their cytotoxicities were assessed using several cancer cell lines, with 1 and 2 exhibiting modest activities.
Highlights
A number of secondary metabolites derived from marine microorganisms have diverse structures and exhibit unexpected biological activities [1,2,3,4]
This motivated us to target marine microorganisms as a source of seed compounds for antitumor chemotherapy agents, and we have reported many cytotoxic metabolites to date [5,6,7,8]
As part of this ongoing study, we examined the metabolites of the fungus Trichoderma harzianum separated from a piece of the marine sponge Halichondria okadai
Summary
A number of secondary metabolites derived from marine microorganisms have diverse structures and exhibit unexpected biological activities [1,2,3,4] This motivated us to target marine microorganisms as a source of seed compounds for antitumor chemotherapy agents, and we have reported many cytotoxic metabolites to date [5,6,7,8]. As part of this ongoing study, we examined the metabolites of the fungus Trichoderma harzianum separated from a piece of the marine sponge Halichondria okadai. We examined the absolute stereostructures of the newly isolated trichodermanins F–H (2–4)
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