Abstract

In this research we study two simple methods, rapid of use spectrophotometric determination of sulphadimadine sodium (SDMS). The fi rst method based on diazotization of drug by sodium nitrite at 5Cº followed by coupling with Salicylic Acid in basic medium to form yellow color. The product was measured at 453 nm. Beer’s law is obeyed in the concentration range of (1-16) ?g?ml-1 . Sandell’s sensitivity was 0.07575 ?g?cm-1, the detection limit was 0.3992 ?g?ml-1, and the limit of Quantitation was 1.07879?g?ml-1. The second method was used cloud point extraction (CPE) with used Triton X-114 as surfactant. Beer’s law obeyed in the range of concentration was (1-12) ?g?ml-1. Sandell’s sensitivity was 0.04 ?g?cm-1, the detection limit was 0.0259 ?g?ml-1, and the limit of quantitation was 0.029563 ?g?ml-1. All variables were study including of the reagent concentration, reaction time. The composition of product (1:1). The methods were effectively useful to the determination of SDMS in pharmaceutical dose form, and the attained results were in good agreement with the offi cial and other methods in literature .No interference was observed from the commonly encountered additives and recipients.

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