Abstract
Two simple, rapid, and useful spectrophotometric methods were suggest or the determination of sulphadimidine sodium (SDMS) with and without using cloud point extraction technique in pure form and pharmaceutical preparation. The first method was based on diazotization of the Sulphdimidine Sodium drug by sodium nitrite at 5 ºC, followed by coupling with α –Naphthol in basic medium to form an orange colored product . The product was stabilized and its absorption was measured at 473 nm. Beer’s law was obeyed in the concentration range of (1-12) μg∙ml-1. Sandell’s sensitivity was 0.03012 μg∙cm-1, the detection limit was 0.0277 μg∙ml-1, and the limit of Quantitation was 0.03605μg∙ml-1.The second method was the cloud point extraction (CPE) using Trtion X-114 as surfactant. Beer’s law was obeyed in the concentration range of (1-12) μg∙ml-1. Sandell’s sensitivity was 0.02958 μg∙cm-1, the detection limit was 0.01745 μg∙ml-1, and the limit of quantitation was 0.028303 μg∙ml-1. All variables including the reagent concentration, reaction time, color stability period, and mole ratio were studied in order to optimize the reaction conditions. The mole ratio for the composition of product is (1:1). Both methods were effectively useful to the determination of sulphdimidine sodium in pharmaceutical dose form. The attained results were in a good agreement with the official and other methods in the literature .No interference were observed from the commonly encountered additives and excipients.
Highlights
Sulfonamides are one of the oldest groups of pharmacologically energetic material used in veterinary medication to day(1) .Their discovery in 1935, suggested the start of a new era in the treatment of a varied range of bacterial diseases and a number of protozoan toxicities(2).The pharmaceutical sulfa of the first antibiotics, terms of manufacturers folic acid were discovered by tincture known as Prontosil (3) which are effective in the body work antibiotics
These salts are useful in the analysis process. They have electrolytic properties that enable them to be combined with other high-density electronic compounds such as phenols and amino acids(7), consisting of colored compounds that are suitable for use in estimating very small amounts of organic compounds, light absorption or polygraphy by measuring the propagation current. These salts can be extracted by cloud point extraction method(8) .Cloud point extraction (CPE)
Vol.16(2)2019 is based on the phase behavior of non- ionic surfactants in aqueous solution(9), which exhibits phase separation after an increase in temperature or the addition of a salting out agent (10).Separation and preconcentration based on (CPE) are becoming an important and practical application of surfactant in analytical chemistry(11).This study focuses to developing easy method and sensitive to determination of Sulphadimidine Sodium (SDMS)
Summary
Sulfonamides are one of the oldest groups of pharmacologically energetic material used in veterinary medication to day(1) .Their discovery in 1935, suggested the start of a new era in the treatment of a varied range of bacterial diseases and a number of protozoan toxicities(2). Sulphadimidine Sodium (SDMS), famous as sulfamethazine Sodium, is one of the greatest broadly used sulfonamides in animals It has supposedly been effectually used contrary to a wide-ranging of contagious diseases, a public healing medication, for livestock, pigs and fowls. These salts are useful in the analysis process They have electrolytic properties that enable them to be combined with other high-density electronic compounds such as phenols and amino acids(7), consisting of colored compounds that are suitable for use in estimating very small amounts of organic compounds, light absorption or polygraphy by measuring the propagation current. These salts can be extracted by cloud point extraction method(8) .Cloud point extraction (CPE). The experimental conditions are free of heating and environmental friendly because small amounts of chemicals are used (12)
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