Abstract
The incidence of pertussis disease declined following widespread immunisation earlier in the twentieth century. However, adverse affects associated with whole-cell pertussis vaccines and recent concern about their efficacy has lead to poor acceptance in a number of countries. Administration of whole-cell pertussis vaccine is associated with a number of undesirable effects such as fever, local reactions and prolonged crying episodes, in addition to rare but serious acute neurological sequelae that may occur in 1 in 100 000 to 1 000 000 vaccinations. Furthermore, recent increases in the incidence of pertussis, even among vaccinated individuals, raise questions regarding the efficacy of the whole-cell vaccine.
Published Version
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