Abstract
Two new binuclear O-bridged copper(II) carboxylates with chemical formulas [Cu2(3-ClC6H4CH2COO)4(phen)2] (1) and [Cu2(3-ClC6H4CH2COO)4(bipy)2] (2) where phen = 1,10-phenanthroline and bipy = 2,2'-bipyridine have been synthesized and characterized by FT-IR, UV-Visible spectroscopy, CHN analysis and single crystal XRD. The results revealed distorted square pyramidal geometry around each copper atom of 1 and 2. The DNA interaction studies showed strong binding with Kb = 5.07 × 103 and 4.62 × 103 M-1 for 1 and 2, respectively. Both complexes showed strong enzyme inhibition, i.e., 70% and 90% for α-glucosidase with IC50 = 34.6 and 30.1 μM for 1 and 2, respectively, where acarbose was employed as control. However, both the complexes were found inactive against α-amylase. Using galantamine hydrobromide as control, 1 showed moderate inhibition activity (47%) with IC50 = 179.4 μM for acetylcholine esterase whereas 2 showed strong inhibition activity (76%) with IC50 = 95.8 μM for butyrylcholine esterase. The data reflects active anti-diabetic and anti-Alzheimer's nature of the synthesized complexes.
Highlights
Despite decades research work in the field of metal carboxylates, these fascinating materials with diverse structures and applications have still kept interest of scientists alive in them
These were obtained in good yield followed by their purification and recrystallization
The bands observed at 673 nm and 663 nm in visible region for complexes 1 and 2, respectively, were assigned to d–d electronic transition of copper metal ion. These band positions are typical of those observed for other copper complexes having square pyramidal geometry
Summary
Despite decades research work in the field of metal carboxylates, these fascinating materials with diverse structures and applications have still kept interest of scientists alive in them. Since their discovery they have been serving mankind in one way or the other. The striking application of metal carboxylates is that they act as accelerators for a number of industrially and biologically important chemical reactions such as oxidations, reductions, couplings, C–H insertions, transformations, and charge transfers.[1,2,3,4] A number of bioactive metal carboxylates have been reported to date.[5,6] Inevitable relationship between chemical reactions naturally carried out within the human body, pharmacology and medicine has lead the scientists to design new bioactive materials in the form of potent drugs for therapeutic intervention in treatment of many life threatening diseases. Interactions with ligands, structure and bonding, Lewis acid character, partially filled d-shell and its redox activity defines its suitability for biological systems.[7,8,9,10]
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