Abstract
The article discusses the new opportunities for improving technology of phototherapy for neonatal jaundice using LED and laser sources in order to reduce the level of bilirubin in the blood of infants. It has been shown that several types of LEDs with emission spectrum corresponding to the long-wavelength slope of bilirubin absorption band can be used for therapeutic purposes. At the same time, the efficacy of phototherapy depend on not only from the position of the maximum in emission spectrum of the LEDs within bilirubin absorption band, but also on the spectral width of acting radiation. Based on the study of regularities of infl of optical radiation on the survival of animal cells in culture sensitized with bilirubin it has been concluded that the damaging eff cts are signifi ly reduced upon transition from quasi-monochromatic LED sources to lasers, emitting in the same spectral range. It allows to consider the modern semiconductor lasers emitting in blue and blue-green spectral regions as promising sources for development of phototherapeutic equipment for treating neonatal hyperbilirubinemia.
Highlights
The development of hyperbilirubinemia syndrome in newborns is due to excessive accumulation in the blood, as well as in the subcutaneous layer of the bile pigment — Z,Z-bilirubin IXα, which gives the skin a characteristic golden yellow color
In the last 7–10 years, in the new development of phototherapeutic equipment for the treatment of hyperbilirubinemia, there has been an active replacement of tube light sources with LED ones
As analysis of the certified equipment for phototherapy of neonatal hyperbilirubinemia on the basis of LED sources available on the world market shows, the developers of phototherapeutic systems do not have a single opinion on the optimal spectral range and radiation intensity to effectively reduce bilirubin levels
Summary
Основным и наиболее распространенным способом лечения неонатальной гипербилирубинемии является фототерапия. В последние 7–10 лет в новых разработках фототерапевтической аппаратуры для лечения гипербилирубинемии наблюдается активная замена ламповых источников света на светодиодные. Как показывает анализ имеющейся на мировом рынке сертифицированной аппаратуры для фототерапии неонатальной гипербилирубинемии на основе светодиодных источников, у разработчиков фототерапевтических систем нет единого мнения об оптимальных спектральном диапазоне и интенсивности излучения для эффективного снижения уровня билирубина. В статье обсуждаются новые возможности совершенствования технологий фототерапии желтухи новорожденных детей при использовании светодиодных и лазерных источников для снижения уровня билирубина в крови младенцев. При этом эффективность фототерапии зависит не только от положения максимума спектра испускания светодиодов в пределах полосы поглощения билирубина, но и от ширины спектра воздействующего излучения. Современные полупроводниковые лазеры синей и сине-зеленой областей спектра в качестве перспективных источников для создания фототерапевтической аппаратуры для лечения гипербилирубинемии новорожденных. Margaryan3 1Institute of Physics, National Academy of Sciences of Belarus, Minsk, Belarus; 2Yerevan State Medical University, Yerevan, Armenia; 3Children’s University Clinic «Muratsan», Yerevan, Armenia
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