Abstract
Molecular biology and conventional toxicology at present provide different answers to the question of whether or not threshold doses exist in the field of “irreversible” toxic effects (chemical carcinogenesis and mutagenesis). The ever-growing number of recognized new and old chemicals showing this type of action, among them unavoidable compounds and even biologically essential elements, warrants quantitative consideration of and research into the basis of activity thresholds for such substances. Biochemical and whole animal experimentation is limited for several reasons; theoretical investigation of this complex problem therefore is urgently needed. Reference is made to a recent theoretical approach which is based on the analogy of essential elements and the activity of foreign compounds.
Published Version
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