New Applications of NMR in Drug Discovery and Development

Abstract

Introduction Part I. Small Molecules, Proteins, Cellular Systems: New Applications of High Resolution NMR in Drug Discovery and Development Solid-state NMR in Drug Discovery and Development High-Resolution NMR-based Metabolic Profiling in Drug Discovery and Development In-Cell NMR Spectroscopy to Study Protein-Drug Interactions Part II. The Whole Organism In Vivo: Increased Sensitivity Using Cryogenic Radiofrequency Coils: Application to In Vivo Phenotyping of Mice Recent Developments of Contrast Agents, CEST and Low Fields Pharmacological fMRI in Drug Discovery and Development In Vivo Proton MR Spectroscopy: Animal and Human Applications at High Fields Hyperpolarization: Concepts, Techniques and Applications Combined PET/MRI for Improving Quantitative Imaging Magnetic Resonance-Based Cell Imaging Using Contrast Media and Reporter Genes Part III. Translational drug discovery: From Biological Models to the Clinics Translational Magnetic Resonance Imaging and Spectroscopy: Opportunities and Challenges In Vivo MRI/S for the Safety Evaluation of Pharmaceuticals Applications of MRI and MRS in Cartilage Therapeutics and Tissue Engineering Applications of Magnetic Resonance Spectroscopy to Psychiatric Disorders Structural Magnetic Resonance Imaging Biomarkers in Neurodegenerative Disease Magnetic Resonance Imaging in Respiratory Diseases: From Diagnosis to Pharmaceutical Research and Development Cardiovascular Magnetic Resonance Magnetic Resonance Imaging Techniques in Cancer Subject Index