Abstract
Marine fungi are a promising source of novel bioactive natural products with diverse structure. In our search for new bioactive natural products from marine fungi, three new phenone derivatives, asperphenone A–C (1–3), have been isolated from the ethyl acetate extract of the fermentation broth of the mangrove-derived fungus, Aspergillus sp. YHZ-1. The chemical structures of these natural products were elucidated on the basis of mass spectrometry, one- and two-dimensional NMR spectroscopic analysis and asperphenone A and B were confirmed by single-crystal X-ray crystallography. Compounds 1 and 2 exhibited weak antibacterial activity against four Gram-positive bacteria, Staphylococcus aureus CMCC(B) 26003, Streptococcus pyogenes ATCC19615, Bacillus subtilis CICC 10283 and Micrococcus luteus, with the MIC values higher than 32.0 µM.
Highlights
Marine filamentous fungi are a rich source of antimicrobial compounds, anti-inflammatory, anticancer and antiviral agents [1–5]
The chemical shifts were given in δ and referenced to the solvent signal (DMSO-d6, δH 2.50, δC 39.5; acetone-d6, δH 2.05, δC 29.8)
The chemical structures of these compounds were elucidated on the basis of HR-ESI-MS, 1D and 2D NMR
Summary
Marine filamentous fungi are a rich source of antimicrobial compounds, anti-inflammatory, anticancer and antiviral agents [1–5]. Among all the marine-sourced fungi, the species in the genus. Aspergillus (Trichocomaceae) are an important source for novel pharmacological metabolites such as polyketides, alkaloids and terpenoids [6–9]. The mangrove plants inhabit the intertidal zones in the tropics and subtropics, providing a very unique habitat for animals and microbes. The mangrove-associated fungi, with the majority coming from endophytic species, have attracted much attention to discover structurally diverse and bioactive secondary metabolites. In the past several years, our research group has explored many novel secondary metabolites from mangrove-derived endophytic fungi, such as sesquiterpenoids diaporols A-I, diaporine with regulation activity of macrophage differentiation and other polyketides [10–12]. As part of our ongoing search for novel biologically active natural products from microbe from special environment [13,14], we chemically investigated an endophytic fungus, Aspergillus sp.
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