Abstract
New bioactive natural products have been recently isolated from marine dinoflagellates, marine-derived fungi, marine sponges, and tunicates. AmphidinolidesG (1), H (2), X (3), and Y (4) are cytotoxicmacrocyclicmetabolites separated from marine dinoflagellates Amphidinium sp. Speradine A (5), modiolides A (7) andB (8), sculezonones A (9) and B (10), seragakinone A (11), dictyonamides A (12) and B (13), and sporiolides A (14) and B (15) are secondary metabolites obtained from marine-derived fungi. The absolute stereochemistry of iejimalide B (17), a cytotoxic macrolide isolated from a marine tunicate, has been determined, while plakevulin A (20), an oxylipin metabolite, has been isolated from an Okinawan marine sponge Plakortis sp. In this review the isolation, structure elucidation, and bioactivities of these marine natural products are described.
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