Abstract
Two new methoxylated flavonoids, setidenosides A (1) and B (2), together with three known constituents, linarin (3), 5-O-E-p-coumarolyquinic acid methyl ester (4), and syringin (5), were isolated from a methanol extract of the aerial parts of Cirsium setidens Nakai (Asteraceae) through bioassay-guided fractionation using advanced glycation end products (AGEs) formation assay. The structures of the new compounds were elucidated by spectroscopic and chemical methods Among these isolated compounds, new compounds 1 and 2 showed significant inhibitory effects on AGEs formation with IC50 values of 6.5 ± 0.2 and 9.7 ± 0.3 μM, respectively. In addition, these two new compounds showed significant radical scavenging capacities in an ONOO− scavenging assay.
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