Abstract
New and Emerging Therapies for Osteoporosis
Highlights
It can be diagnosed by dual-energy X-ray absorptiometry (DXA), even before a fracture has occurred, using the World Health Organization (WHO) criteria according to the patient’s T-score
Even when treatment is taken correctly and for a sufficient length of time for the patient to benefit from reduction in fracture risk, there may be limitations in effectiveness, limitations in the duration of therapy, and concerns regarding long-term safety, such as atypical femur fractures and osteonecrosis of the jaw with bisphosphonates
Wnt signaling initiated by the binding of Wnt proteins to the low density lipoprotein-related protein (LRP5/6)frizzled receptor complex has recently been recognized as an important upregulator of osteoblastic bone formation; sclerostin and Dickkopf-1 (DKK-1) are natural inhibitors of
Summary
Wnt signaling initiated by the binding of Wnt proteins to the low density lipoprotein-related protein (LRP5/6)frizzled receptor complex has recently been recognized as an important upregulator of osteoblastic bone formation; sclerostin and Dickkopf-1 (DKK-1) are natural inhibitors of. E. Michael Lewiecki,1 Manuel Diaz Curiel,2 Joao Lindolfo Borges,3 Annie Kung,4 Maria Luisa Brandi,5 and Hans Peter Dimai6
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
