Abstract
New and Emerging Therapies for Osteoporosis
Highlights
It can be diagnosed by dual-energy X-ray absorptiometry (DXA), even before a fracture has occurred, using the World Health Organization (WHO) criteria according to the patient’s T-score
Even when treatment is taken correctly and for a sufficient length of time for the patient to benefit from reduction in fracture risk, there may be limitations in effectiveness, limitations in the duration of therapy, and concerns regarding long-term safety, such as atypical femur fractures and osteonecrosis of the jaw with bisphosphonates
Wnt signaling initiated by the binding of Wnt proteins to the low density lipoprotein-related protein (LRP5/6)frizzled receptor complex has recently been recognized as an important upregulator of osteoblastic bone formation; sclerostin and Dickkopf-1 (DKK-1) are natural inhibitors of
Summary
Wnt signaling initiated by the binding of Wnt proteins to the low density lipoprotein-related protein (LRP5/6)frizzled receptor complex has recently been recognized as an important upregulator of osteoblastic bone formation; sclerostin and Dickkopf-1 (DKK-1) are natural inhibitors of. E. Michael Lewiecki,1 Manuel Diaz Curiel,2 Joao Lindolfo Borges,3 Annie Kung,4 Maria Luisa Brandi,5 and Hans Peter Dimai6
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