New Alkaloid from Aspidosperma Polyneuron Roots

Abstract

The roots of Aspidosperma polyneuron, family Apocynaceae, were subjected to chemical and biological investigations. From an ethanolic extract of the roots, the new alkaloid 2,7-dihydroxyquebrachamine (1) was isolated. The structure was established mainly from 1D and 2D NMR spectroscopic and mass spectrometric data. The 1D and 2D NMR spectra were also used to assign all the 1H and 13C chemical shifts of this alkaloid. Artemia salina was used for a preliminary investigation of biological activity.