Abstract
Two pairs of diastereoisomeric acetylenic norlignan compounds with PhCH(OR1)CH(OR2)CH2C≡CPh skeleta: (1R, 2R)-1-O-methylnyasicoside (1) and (1S, 2R)-1-O-methylnyasicoside (2), and (1R, 2R)-crassifogenin D (3) and (1S, 2R)- crassifogenin D (4), were isolated from the ethanolic extract of rhizomes of Curculigo crassifolia. Compounds 3 and 4 are new and their structures were elucidated on the basis of spectroscopic evidence and comparisons with literature data.
Highlights
Curculigo crassifolia (Bak.) Hook. f. belongs to the Hypoxidaceae family and is found throughout the Western and Southern regions of China
The 95% EtOH extract of air-dried and powdered rhizomes of C. crassifolia was suspended in H2O
Further repeated column chromatography of the EtOH eluted residue on silica gel and Sephadex LH-20 led to the isolation of two pairs of acetylenic norlignan compounds with PhCH(OR1)CH(OR2)CH2C≡CPh skeletons
Summary
Curculigo crassifolia (Bak.) Hook. f. belongs to the Hypoxidaceae family and is found throughout the Western and Southern regions of China. Further repeated column chromatography of the EtOH eluted residue on silica gel and Sephadex LH-20 led to the isolation of two pairs of acetylenic norlignan compounds with PhCH(OR1)CH(OR2)CH2C≡CPh skeletons. D +26.50o (c 0.16, MeOH), was obtained as a white amorphous powder and assigned a molecular formula of C24H28O11 on the basis of the HRFAB-MS (-)
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