Abstract
Thymine, 5-FU, and uracil were successfully synthesized through a procedure involving a cyclocondensation of triphosgene with newly developed α-substituted β-aminoacrylamides intermediates (la, X= Me; 1b, X= F; 1c, X= H). The radioligands [2- 11 C]thymine and [2- 11 C]5-fluorouracil were synthesized in high radiochemical yields in 16-17 minutes from the end of bombardment by applying the cyclocondensation method with [ 11 C]COCl 2 .
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