Abstract
Stroke has been known as the second greatest cause of mortality and the third cause of disability. Ischemic stroke is more frequent than hemorrhagic stroke. The pathophysiology of ischemic stroke relates with inflammatory process. Neutrophil and lymphocyte are part of that process. Routine peripheral hematological laboratory, which contains information of neutrophil and lymphocyte, is easy, cheap and rapid test. This literature review purposes to explain the modality of neutrophil-lymphocyte ratio (NLR) in predicting the recurrence, disability and mortality of ischemic stroke following acute phase.
Highlights
Stroke is a sudden neurological deficit which is caused by vascular and can be focally or globally (1)
The other cut-off of neutrophil-lymphocyte ratio (NLR) was 7 and related with poor outcome (OR = 2.44; 95%CI; 1.73– 3.42) (34). This is consistent with Hu, who reported that NLR ≥ 5.87 showed the poor outcome in 3 months after ischemic stroke (OR = 2.079; 95%CI; 1.232-3.506; p = 0.006) with 64.4% sensitivity and 59.2% specificity
This study showed that NLR≥ 4.58 had 5.58 times suffered moderate-severe disability than NLR≤ 4.58 (95%CI; 1.99-15.64, p = 0.001) (36) (Table 1)
Summary
Stroke is a sudden neurological deficit which is caused by vascular and can be focally or globally (1). The irregularly control fails to have proper secondary management It promotes the chance of having recurrent stroke. The recurrent ischemic stroke is caused by both irregularly control and various risk factors of stroke. Stroke survivor has limitation to do activity daily living (ADL) because alteration in mobility, behavior, emotion, and articulation This limitation can be one of the recurrent stroke risk factors. NLR can be used to predicting the recurrence of ischemic stroke This inexpensive, rapid and universal laboratory test as peripheral hematological test (such as, hemoglobin, leukocyte, platelet, and differential white cell count (neutrophil, lymphocyte, monocyte, basophil, eosinophil) is routinely checked, especially in emergency room (12). This review aims to outline the modality of NLR ratio in predicting the recurrence, disability and mortality of ischemic stroke following acute phase
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