Abstract
Systems capable of precise motion in the vasculature can offer exciting possibilities for applications in targeted therapeutics and non-invasive surgery. So far, the majority of the work analysed propulsion in a two-dimensional setting with limited controllability near boundaries. Here we show bio-inspired rolling motion by introducing superparamagnetic particles in magnetic and acoustic fields, inspired by a neutrophil rolling on a wall. The particles self-assemble due to dipole–dipole interaction in the presence of a rotating magnetic field. The aggregate migrates towards the wall of the channel due to the radiation force of an acoustic field. By combining both fields, we achieved a rolling-type motion along the boundaries. The use of both acoustic and magnetic fields has matured in clinical settings. The combination of both fields is capable of overcoming the limitations encountered by single actuation techniques. We believe our method will have far-reaching implications in targeted therapeutics.
Highlights
Systems capable of precise motion in the vasculature can offer exciting possibilities for applications in targeted therapeutics and non-invasive surgery
Micro-sized superparamagnetic particles are injected into the channel, after which a rotating magnetic field is applied
As soon as the acoustic field is activated, the collected particles migrate to the boundary, and a subsequent rolling motion is achieved along the vessel wall
Summary
Systems capable of precise motion in the vasculature can offer exciting possibilities for applications in targeted therapeutics and non-invasive surgery. The aggregate migrates towards the wall of the channel due to the radiation force of an acoustic field By combining both fields, we achieved a rolling-type motion along the boundaries. We achieved a rolling-type motion along the boundaries The use of both acoustic and magnetic fields has matured in clinical settings. Limited work exists regarding propulsion within microchannels or in a confined geometry Both acoustically[24,25,26,27,28,29,30,31] and magnetically powered microswimmers can potentially be used in the human body. We have demonstrated rolling motion along the walls of rectangular and circular microchannels
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