Abstract
Summary The neutralizing activity of sera from guinea-pigs inoculated with small-plaque (SP) and large-plaque (LP) variants of foot-and-mouth disease virus (FMDV) was studied. Virus neutralization tests were performed in suckling mice using the SP and LP variants as well as a low passage virus of the same type and strain. Higher titres were obtained with homologous virus than when a vims of low passage in tissue culture was used. Neutralizing activity was not demonstrable in some guinea-pig sera with a low passage virus, whereas a significant level of neutralizing activity was detected when homologous virus-serum mixtures were tested.
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