Abstract
phosphorylation on Kv1.5. Co-immunoprecipitation experiments showed that in both co-transfected cells, and in postmortem human cardiac tissue, Kv1.5 associates with src. This association is mediated presumably through the SH3 domain on src and an SH3-binding motif in the N terminus of human Kv1.5, as rat Kv1.5, which lacks this motif, is unable to interact with src. Interestingly, many different K+ channels have SH3-binding motifs, suggesting that interaction with src and other SH3-containing proteins might occur for other channels as well. Morgan Sheng (Boston, MA, USA) discussed the interaction of shaker-family K+ channels with the PSD-95/DLG family of cytoskeletal-associated proteins. New evidence was presented supporting a role for the Drosophila discs large (DLG) protein in localizing shaker K+ channels in vivo.
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