Neuropsychiatrie disorders in Parkinson's disease and their correction with the MAO-B inhibitor rasagiline (Azilect®)

Abstract

Parkinson's disease (PD) is a multisystemic neurodegenerative disease with a broad spectrum of not only movement, but also neuropsychiatry disorders (NPD). The efficiency of dopamine therapy in correcting NPD needs to be clarified. Objective: to evaluate the impact of therapy with the MAO-B inhibitor rasagiline (Azilect®) on NPD in patients with extended stages of PD. Subjects and methods. Twenty PD (disease duration 10.2+5.08 years; stage 2.4+0.5) patients with the wearing-of phenomenon were given rasagiline ' mg/day in addition to antiparkinsonian drugs. Following 6 and 24 weeks of therapy, its efficiency was evaluated using the unified PD rating scale, the motor fluctuation rating scale, the Beck depression inventory, the PD fatigue scale, the PD sleep scale, the Epworth sleeping scale, and the PD quality of life scale (PDQ-39). Results. There were reductions in the severity of nocturnal and morning hypokinesia, daytime off periods, depression, insomnia, overfatigue and improved quality of life. The positive effect of therapy was stable within further 6 follow-up months.