Abstract
Aims: The purpose of the present study was targeted to explore the possible role of thymol against global cerebral ischemia-reperfusion injury in albino rats.
 Study Design: Healthy Albino Wistar rats (200–250 gm) were divided randomly into 5 groups (n=6). Group I and II were considered as normal control and sham control, received 2% tween 80 orally, group III was ischemic- reperfusion (disease control) and received 2% tween 80 orally and Group IV and V received thymol at doses of 50 mg/kg, per oral and 100 mg/kg, per oral. respectively.
 Place and Duration of Study: Department of Pharmacology, Sri Padmavathi School of pharmacy, Tiruchanur, Tirupati in between Sept 2019 to March 2020.
 Methodology: Group I and II were considered as normal control and sham control, received 2% tween 80 orally, group III was ischemic- reperfusion (disease control) and received 2% tween 80 orally and Group IV and V received thymol at doses of 50 mg/kg, per oral (p.o) and 100 mg/kg, per oral (p.o). respectively. After pretreatment with thymol for 2 weeks, rats were subjected to bilateral common carotid artery occlusion for 1 hour accompanied by 22 hours reperfusion (I/R). After 22 hrs of reperfusion, motor coordination, hanging wire test, despair swim tests were studied. Antioxidant levels of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and pro-oxidant level of Malondialdehyde (MDA) were analyzed in brain tissue homogenate. Changes in cerebral infarct size and histopathology were studied.
 Results: Pretreated groups of thymol (50 and 100 mg/kg p.o) showed significant improvement in neurobehavioral changes and attenuated oxidative damage as indicated by reduced LPO, restored GSH, SOD and CAT levels and decreased infract size when compared to ischemic reperfusion group.
 Conclusion: This study suggests that thymol may have a beneficial role against global ischemia reperfusion induced damage caused by excessive free radicals and behavioral alterations in rats.
Highlights
Ischemic stroke happens because of the abrupt impediment of the blood vessel by a thrombus or embolism, is a typical reason for death and inability around the world. [1] Ischemia is a limitation in the supply of blood to tissues, gives rise to the absence of glucose and oxygen required for the metabolism of cell
This study suggests that thymol may have a beneficial role against global ischemia reperfusion induced damage caused by excessive free radicals and behavioral alterations in rats
This research was focused on thymol, a naturally occurring phytochemical against the global cerebral ischemia reperfusion model in albino rats
Summary
Ischemic stroke happens because of the abrupt impediment of the blood vessel by a thrombus or embolism, is a typical reason for death and inability around the world. [1] Ischemia is a limitation in the supply of blood to tissues, gives rise to the absence of glucose and oxygen required for the metabolism of cell. Numerous neuroprotective drugs indicated gainful impacts in preclinical investigations either flopped in clinical preliminary, showed extreme symptoms or declined the result of stroke The purpose behind this is obvious disparity between tests on animals and clinical application which are multifactorial.[4,5] One of reason for the disappointment of evolved drugs can focus on single sub-atomic pathway, while a couple of pathways are included spatially and transiently in the pathophysiology of stroke. A white crystalline monoterpene phenol, known as 2 isopropyl-5-methylphenol having strong flavor and pleasant aromatic odor It seemed to have many pharmacological properties containing anticonvulsant,[7] antifungal,[8] antihyperlipidemic, antioxidant,[9] antispasmodic, anti-inflammatory,[10] antiseptic, antiepileptogenic, radioprotective[11] and antitumor activities[12]. This research was focused on thymol, a naturally occurring phytochemical against the global cerebral ischemia reperfusion model in albino rats
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