Abstract
The effect of salidroside on hemisection-induced spinal cord injury (SCI) in rats was investigated. The Sprague Dawley (SD) rats were randomly divided into six groups: Sham control group, SCI model group, the methylprednisolone sodium succinate (MPSS) group, the salidroside-low dosage group, the salidroside-moderate dosage group and the salidroside-high dosage group. The SD rats were hemisected at spinal cord at the T8 vertebra to establish SCI models. 24 h after operation, different dosage of salidroside increased the superoxide anion (O2−) level and superoxide dismutase (SOD) activity, and reduced malondialdehyde (MDA) content. Noticeably, salidroside at the 100 mg/kg dosage exhibited similar effects as MPSS, which has been frequently used for clinical acute SCI. These results suggested that salidroside can significantly suppress oxidation in acute SCI. Key words: Salidroside, spinal cord injury (SCI), oxidation.
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