Abstract
The effect of salidroside on Bcl-2/Bax protein levels in rats with hemisection-induced spinal cord injury (SCI) was studied. The Sprague Dawley (SD) rats were randomly divided into six groups: Sham operation group, SCI model group, methylprednisolone sodium succinate (MPSS) treatment group, salidroside-low dosage treatment group, salidroside-moderate dosage treatment group, and salidroside-high dosage treatment group. The SD rats were hemisected at the spinal cord, at the T8 vertebra to establish SCI model. 24 h after operation, different dosage of salidroside increased and reduced the protein levels. Noticeably, salidroside at the 100 mg/kg dosage exhibited similar effects as MPSS, which has been frequently used for clinical acute SCI. These results suggested that salidroside can significantly inhibit apoptosis in acute SCI. Key words: Salidroside, spinal cord injury (SCI), Bcl-2/Bax, apoptosis.
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