Neuroprotective Effect of Grewia carpinifolia Extract against Behavioral Impairments Induced by Vanadium

Abstract

Vanadium is a heavy metal that has been reported to cause toxicity in the central nervous system resulting in various behavioral alterations. This is characterized by the generation of reactive oxygen species. The present study was designed to investigate the probability of Grewia carpinifolia ethanol extract in preventing behavioral impairments following acute vanadium toxicity in mice. Twenty five Swiss albino mice (25–27g) were randomized into 5 groups (A–E) of 5 animals each. Group A received distilled water and served as a control; group B received vitamin E (500mg·kg−1 b.w. every 72 hours), a known antioxidant orally along with a daily dose of sodium metavanadate intraperitoneally (i.p.) for 7 days; group C and group D received Grewia carpinifolia leaf extract at 100 and 200mg·kg−1 b.w orally respectively, along with the sodium metavanadate i.p. for 7 days; while group E received sodium metavanadate i.p. only for 7 days. The behavioral and motor functions were analyzed by the open field, negative geotaxis, and hanging wire tests; the daily body and brain weights were recorded. Grewia carpinifolia ethanol extracts significantly reduced the number of grooming, stretched attend posture, and freezing time that were significantly increased in the vanadium only group and also enhanced the vestibular functions. Furthermore, the latent time spent on the hanging wire in groups simultaneously administered with the extract and vanadium compared positively (P>0.05) with the control groups but a decrease in latent time was observed in the vanadium only group. The results suggest that acute vanadium toxicity results in various behavioral impairments and support a possible role of Grewia carpinifolia as a protective agent against acute vanadium-toxicity with a better result at 200mg·kg−1 b.w. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.