Abstract
AimTo evaluate the neuroprotective activity of Hibiscus abelmoschus Linn. against Parkinson’s Disease in rat model. Materials and methodsNeuroprotective activity was carried out on Parkinson’s Disease by inducing striatal 6-OHDA lesions in SD rats. The behavioral studies such as behavioral assessment, muscular coordination, locomotor activity, and open field were performed along with enzymatic and non-enzymatic antioxidants level were estimated. Striatal infarction area and histopathological studies were also performed. ResultsThe hydroalcohol extract of Hibiscus abelmoschus Linn. showed neuroprotective activity against Parkinson’s Disease by positive response in behavioral studies including significant decrease in lipid peroxidation (LPO) and increase in superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and total thiol levels in extract treated groups as compared to control group. Striatal infarction area was significantly reduced in extract treated groups as compared to control group. Histopathological studies also shows a significant effect of extract. ConclusionThe hydroalcohol extract of Hibiscus abelmoschus Linn. Showed neuroprotective against Parkinson’s Disease in rat model.
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