Neuroprotective Activity of Berberis aristata against 6‐OHDA Induced Parkinson's Disease Model

Abstract

ObjectiveTraditionally, the plant is used for various diseases, including neuronal disorders. To evaluate the neuroprotective activity of Berberis aristata DC.against 6‐OHDA Parkinson's disease in rat model.Materials and methodsParkinson's disease was induced by the striatal 6‐OHDA lesions. The behavioral assessments such as spontaneous locomotor activity, muscular coordination, and open field were studied along with antioxidant enzymatic and non‐enzymatic levels were estimated. Striatal infraction area, volume, estimation of Dopamine level was done by LC/MS/MS method. The histophathological studies were performed.ResultsThe Berberis aristata DC. methanol extract showed anti‐Parkinson's disease activity by increase in behavioural activity and muscular coordination, decrease in clockwise rotation and in biochemical estimation there was significant decrease in lipid peroxidation (LPO) and increase in superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and total thiols levels in extract treated groups as compared to control group. Striatal infraction area and volume was significantly reduced in extract treated groups as compared to control group.ConclusionThe methanol extract of Berberis aristata DC.showed potent neuroprotective activity against 6‐OHDA induced Parkinson's disease in rat model.