Neuropharmacological Effects of Quercetin: A Literature-Based Review

Md Shahazul Islam,Assem Mamurova,Nazgul Altybaeva,Muhammad Torequl Islam,Anca Oana Docea,Bagila Abdullayeva,Daniela Calina,Ainur Seilkhan,Rajib Hossain,Ahmed Al-Rawahi,Javad Sharifi-Rad,Cristina Quispe,Miquel Martorell,Ahmed Al-Harrasi

doi:10.3389/fphar.2021.665031

Abstract

Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its beneficial properties in many pathologies. Its neuroprotective effects have been demonstrated in many in vitro studies, as well as in vivo animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer’s disease, Amyloid β peptide, Parkinson’s disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases.

Highlights

Neuropharmacology is the investigation of what medications mean for cell work in the sensory system and the neural components with its mechanisms through which they impact behavior (Yeung et al, 2018)
For this updated review, were included: in extenso papers written in the English language, in vitro and in vivo experimental studies that showed the effective doses compared with control and studies hich highlighted the molecular mechanisms of the neuroprotective effects of QUR
This study showed that when encapsulated in phytosmes, QUR has a bioavailability of 50 times higher compared to QUR standard products

Summary

Introduction

Neuropharmacology is the investigation of what medications mean for cell work in the sensory system and the neural components with its mechanisms through which they impact behavior (Yeung et al, 2018). Quercetin (QUR, C15H10O7), known as 3,3′,4′,5,7-pentahydroxyflavone (Figure 1), is a unique bioflavonoid, plentifully found in various leafy foods and fruits e.g. apples, berries, chokeberries cilantro, dill, escapades, lingonberries, lovage, onions (Yang et al, 2020; Sharifi-Rad et al, 2021b) It exhibits several biopharmacological activities (Kawabata et al, 2015), including antioxidant (Chaudhary et al, 2015) and antiinflammatory (Kim and Park, 2016; Zheng et al, 2016) activities, neuroprotective properties against CNS disorders, including memory impairment (Nassiri-Asl et al, 2013; Abdalla et al, 2014; Zhang et al, 2016), seizure (Nieoczym et al, 2014; Nassiri-Asl et al, 2016), Huntington’s disease (HD) (Chakraborty et al, 2014), and PD (Gomez del Rio et al, 2013). QUR is clearly a polar auxin transport antagonist (Fischer et al, 1997)

Methods

Findings

Discussion

Conclusion