Abstract
Effects of aqueous leaf extracts of bryophyllum pinnatum (AEBP) on someneuropharmacological activities were studied in mice. The extract indosages (50,100 and 200 mg/kg) was found to produce a profounddecrease in exploratory activity in a dose-dependent manner. It alsoshowed a marked sedative effect as evidenced by a significant reduction ingross behaviour and potentiation of pentobarbitone-induced sleeping time.It delayed onset in strychnine-and picrotoxin-induced convulsion (seizures)respectively with the protective effect being significantly higher inpicrotoxin- than strychnine-induced convulsion. It also decreases the rateof picrotoxin-induced mortality in mice with LD50 of 641mg/kg. Thetotality of these effects showed that the extract possesses depressantaction on the central nervous systemKeywords: Bryophyllum pinnatum, Neuropharmacology, exploration, anticonvulsant, muscle relaxant.
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