Abstract
The neuropeptide research in the eye began in the 80�s with the investigation of the presence and distribution of substance P (SP), calciton in gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY). SP and CGRP have been found to be constituents of the sensory innervation of the eye whereas VIP can be attributed to the parasympathetic and NPY to the sympathetic innervation. In general, a widespread but moderate innervation was commonly found for neuropeptides with sparse nerve fibers being present in the corneal stroma, surrounding blood vessels at the limbus, in their irideal stroma and both in association to the sphincter and dilator muscle, in the stroma of the ciliary body at the base of the processes, in the stroma of the processes as well and finally in the choroid.
Highlights
The neuropeptide research in the eye is the main topic of our scientific group in Innsbruck
Whereas substance P (SP) and calcitonin gene-related peptide (CGRP) have been found to be constituents of the sensory innervation of the eye, vasoactive intestinal polypeptide (VIP) is present in the parasympathetic and neuropeptide Y (NPY) in the sympathetic innervation of the eye
The innervation of the eye by several further peptides has been explored including galanin, somatostatin, cholecystokinin, nitric oxide, pituitary adenylatecyclase (PACAP) and neurokinin A and the results of these explorations have been reviewed in the year 2007 by our scientific group in Innsbruck in “Brain Research Reviews” and in the book “Neuropeptides in the eye” which has been released in 2009 in “Research Signpost”
Summary
The neuropeptide research in the eye is the main topic of our scientific group in Innsbruck. Most of the neuropeptides have been discovered more than 30 years ago and the presence and distribution of some of them has been explored in the eye in the 80 ́s mainly by Richard Stone.
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