Abstract
Neuropeptides play a variety of roles in many physiological processes and serve as potential therapeutic targets for the treatment of some nervous-system disorders. In recent years, there has been a tremendous increase in the number of identified neuropeptides. Therefore, we have developed NeuroPep, a comprehensive resource of neuropeptides, which holds 5949 non-redundant neuropeptide entries originating from 493 organisms belonging to 65 neuropeptide families. In NeuroPep, the number of neuropeptides in invertebrates and vertebrates is 3455 and 2406, respectively. It is currently the most complete neuropeptide database. We extracted entries deposited in UniProt, the database (www.neuropeptides.nl) and NeuroPedia, and used text mining methods to retrieve entries from the MEDLINE abstracts and full text articles. All the entries in NeuroPep have been manually checked. 2069 of the 5949 (35%) neuropeptide sequences were collected from the scientific literature. Moreover, NeuroPep contains detailed annotations for each entry, including source organisms, tissue specificity, families, names, post-translational modifications, 3D structures (if available) and literature references. Information derived from these peptide sequences such as amino acid compositions, isoelectric points, molecular weight and other physicochemical properties of peptides are also provided. A quick search feature allows users to search the database with keywords such as sequence, name, family, etc., and an advanced search page helps users to combine queries with logical operators like AND/OR. In addition, user-friendly web tools like browsing, sequence alignment and mapping are also integrated into the NeuroPep database.Database URL: http://isyslab.info/NeuroPep
Highlights
Neuropeptides are small proteineous substances that are produced by neurons, released in a regulated fashion, and act on either neural substrates, such as neurons, glial cells or on non-neuronal target cells, such as a gland or muscle [1]
Since the first neuropeptide substance P was discovered by van Euler and Gaddum in 1931 [8] and sequenced in 1971 [9], there has been a tremendous increase in the number of identified neuropeptides over the last 40 years
The 5949 non-redundant entries cover 493 organisms belonging to 65 different neuropeptide families
Summary
Neuropeptides are small proteineous substances that are produced by neurons, released in a regulated fashion, and act on either neural substrates, such as neurons, glial cells or on non-neuronal target cells, such as a gland or muscle [1]. Since the first neuropeptide substance P was discovered by van Euler and Gaddum in 1931 [8] and sequenced in 1971 [9], there has been a tremendous increase in the number of identified neuropeptides over the last 40 years. Due to their wide range of roles in health and disease, neuropeptides are considered as attractive therapeutic targets for nervous-system disorders such as depression, anxiety and Parkinson’s disease [10,11,12]. There are only two recent databases specific for neuropeptides
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